Missteps in Current Estimates of Cancer Overdiagnosis
نویسندگان
چکیده
منابع مشابه
Overdiagnosis in cancer.
This article summarizes the phenomenon of cancer overdiagnosis-the diagnosis of a "cancer" that would otherwise not go on to cause symptoms or death. We describe the two prerequisites for cancer overdiagnosis to occur: the existence of a silent disease reservoir and activities leading to its detection (particularly cancer screening). We estimated the magnitude of overdiagnosis from randomized t...
متن کاملConceptualizing overdiagnosis in cancer screening.
The aim of cancer screening is to detect asymptomatic cancers whose treatment will result in extension of life, relative to length of life absent screening. Unfortunately, cancer screening also results in overdiagnosis, the detection of cancers that, in the absence of screening, would not present symptomatically during one's lifetime. Thus, their detection and subsequent treatment is unnecessar...
متن کاملEstimation of Overdiagnosis in Breast Cancer Screening
I. Summary The benefit of breast cancer (BC) screening with mammography has been demonstrated by randomized controlled trials (RCTs). However, there is a growing concern about the harms of screening, in particular the problem of overdiagnosis. It occurs when screening detects a breast cancer that would not have presented clinically in the woman's lifetime in the absence of screening. Overdiagno...
متن کاملInterpreting Overdiagnosis Estimates in Population-based Mammography Screening
Estimates of overdiagnosis in mammography screening range from 1% to 54%. This review explains such variations using gradual implementation of mammography screening in the Netherlands as an example. Breast cancer incidence without screening was predicted with a micro-simulation model. Observed breast cancer incidence (including ductal carcinoma in situ and invasive breast cancer) was modeled an...
متن کاملA critical appraisal of overdiagnosis: estimates of its magnitude and implications for lung cancer screening.
BACKGROUND The magnitude of overdiagnosis is a critical and unresolved issue in lung cancer (LC) screening:(1) its contribution to the increase in survival constitutes specious evidence of benefit;(2) overdiagnosed individuals who undergo resection will experience a reduction in life expectancy, partially or completely offsetting the benefit received by others in whom earlier intervention prove...
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ژورنال
عنوان ژورنال: Academic Radiology
سال: 2017
ISSN: 1076-6332
DOI: 10.1016/j.acra.2016.05.020